Lipid – Communicable Diseases Research

Identification and characterization of the anti-SARS-CoV-2 activity of cationic amphiphilic steroidal compounds

양이온성 양친매성 스테로이드 화합물의 항 SARS-CoV-2 활성의 확인 및 특성화

Article

Published on 2022-12-012022-09-11
Journal: Virulence
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제,

[키워드] aggravation ameliorated anti-SARS-CoV-2 activities Anti-SARS-CoV-2 Activity Antiviral antiviral activity cationic caused cell lines characterization cholesterol complex Compound compounds COVID-19 pandemic COVID-19 patient cytopathic Cytopathic effect Drug discovery effective envelope envelope proteins epiandrosterone followed by hACE2 HEK293 host cell host cells identification in vitro in vivo indicated inhibited initial involved life Lipid mechanism membrane modulate modulation Mortality Pathogenesis progeny protective effect Protective effects Proteins Quality of life reduce reduce COVID-19 aggravation SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selected Selection single mutation single mutations specific treatment spike steroidal compounds. subversion Transgenic mouse translate transmembrane Treatment treatment of COVID-19 patients Vero Vero CCL81 cell Vero CCL81 cells viral replication Viral RNA viral variant Viral variants
[DOI] 10.1080/21505594.2022.2085793 PMC 바로가기 [Article Type] Article

Epigenetic perspectives of COVID-19: Virus infection to disease progression and therapeutic control

Research article

Published on 2022-12-012022-10-05
Journal: Biochimica et biophysica acta. Molecular basis of
[Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제,

[키워드] ACE2 analysed antagonistic autophagy caused Cell cellular metabolism cellular processe Course COVID-19 death Disease progression enzyme Epigenetic epigenetics example expression profile function genes encoding Genome Host host cell IL-6 Infection investigated Laboratory Lipid mechanism membrane metabolic activity metabolic pathway methionine pathogen invasion patients Perspective progression rDNA Regulation replication mechanism ribosome S-adenosylmethionine SARS-CoV-2 sera social isolation the disease the patient therapeutic therapy tissue viral loads virus virus particle virus replication
[DOI] 10.1016/j.bbadis.2022.166527 [Article Type] Research article

An efficient approach for SARS-CoV-2 monoclonal antibody production via modified mRNA-LNP immunization

Article

Published on 2022-11-052022-11-15
Journal: International journal of pharmaceutics
[Category] COVID19(2023년), SARS, 변종, 진단,

[키워드] addition Antigen antigens applied approach approaches binding affinity circumvent complementary COVID-19 COVID-19 pandemic Delta Diseases evaluated functional fusion strategy generate immunization introduced lack Lipid Lipid nanoparticle (LNP) LNP mAb mAbs Membrane proteins methodology mice Modified mRNA monoclonal antibodies monoclonal antibody neutralize Neutralizing Neutralizing activity posttranslational modification Prophylactic Protein RBD Receptor binding domain SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike SARS-CoV-2 virus SARS-CoV-2. serum serum antibody several variants therapeutic drug Treatment Vaccines variants
[DOI] 10.1016/j.ijpharm.2022.122256 PMC 바로가기

Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virus

Article

Published on 2022-10-172022-11-15
Journal: Signal Transduction and Targeted Therapy
[Category] COVID19(2023년), SARS, 치료제,

[키워드] Activation administration antiviral target cell injury Combination COVID-19 Critical Cytokine storm dependent on drugs facilitate FFA FFAs free fatty acid Host humans IAV Infection influenza A virus inhibitor inhibitors investigated late stage LDs limit Lipid lipid droplet lipolytic lung lung lesion Malnutrition membrane transporter mice mitigate Mortality outbreak pandemic patients pharmacological Proinflammatory cytokine PROTECT reduce Replication replication of SARS-CoV-2 rescued RNA RNA virus SARS-CoV-2 SARS-CoV-2-infected hamsters significantly suppressed therapeutic target Treatment viral infections virus virus-infected cell
[DOI] 10.1038/s41392-022-01223-4 PMC 바로가기

mRNA-1273 but not BNT162b2 induces antibodies against polyethylene glycol (PEG) contained in mRNA-based vaccine formulations

Article

Published on 2022-10-062022-11-15
Journal: Vaccine
[Category] 진단, 치료기술,

Emerging Applications of Electrochemical Impedance Spectroscopy in Tear Film Analysis

Article

Published on 2022-10-052022-11-15
Journal: Biosensors
[Category] 바이오마커,

A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs

Research article

Published on 2022-10-012022-10-05
Journal: Journal of controlled release : official journal o
[Category] 신약개발,

Development of a multiomics model for identification of predictive biomarkers for COVID-19 severity: a retrospective cohort study

Research article

Published on 2022-09-012022-10-05
Journal: International Journal of Environmental Research an
[Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 진단,

[키워드] absence adverse outcomes analysed approach assigned Biomarker Biomarkers Classifier CLEC6A Clinical improvement Clinical outcome Clinical use Cohort cohorts collected complex complications Course COVID-19 COVID-19 pandemic Critical cytokine Cytokines dataset defined development disease disease severity disorder domain Eric ether example finding funding high variability hospital Hospital admission independent Lipid lipids machine Machine learning algorithms marker Mayo Clinic metabolite metabolites molecular MOST multidimensional outcome participant Patient patients with COVID-19 plasma plasma sample positive predict predicted Predictive producing Protein Proteins proteomics proximity extension assay quantified reported representing retrospective cohort study SARS-CoV-2 RT-PCR severity subgroup subset Tandem mass spectrometry the WHO USA was done with COVID-19
[DOI] 10.1016/S2589-7500(22)00112-1 [Article Type] Research article

Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine

Article

Published on 2022-08-232022-11-16
Journal: ACS Nano
[Category] COVID19(2023년), SARS, 치료기술,

Lipid lowering effects of the CETP inhibitor obicetrapib in combination with high-intensity statins: a randomized phase 2 trial

Research

Published on 2022-08-112022-10-05
Journal: Nature Medicine
[Category] 임상,